TRIM33 [The Human Chemical-Genetic Interaction Map Project]

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======= TRIM33 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM33
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 33
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51592|51592]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPN9|Q9UPN9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM33&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM33|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605769|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-B box|
|PHD|
|Bromodomain|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|co-SMAD binding|
|R-SMAD binding|
|negative regulation of BMP signaling pathway|
|regulation of BMP signaling pathway|
|regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of cellular response to growth factor stimulus|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|ubiquitin-protein transferase activity|
|regulation of cellular response to growth factor stimulus|
|protein ubiquitination|
|protein modification by small protein conjugation|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|protein modification by small protein conjugation or removal|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of response to stimulus|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.45|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.43|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-2.34|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.2|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.08|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.84|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.74|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.75|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.82|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.91|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.36|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.91|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|3.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:id3|ID3]]|0.555|
|[[:human genes:f:fbxo11|FBXO11]]|0.538|
|[[:human genes:r:runx1|RUNX1]]|0.487|
|[[:human genes:s:ssbp2|SSBP2]]|0.486|
|[[:human genes:m:mtor|MTOR]]|0.478|
|[[:human genes:m:maml1|MAML1]]|0.473|
|[[:human genes:c:cbfb|CBFB]]|0.467|
|[[:human genes:m:med23|MED23]]|0.467|
|[[:human genes:z:znf592|ZNF592]]|0.46|
|[[:human genes:d:dcaf5|DCAF5]]|0.456|
|[[:human genes:c:ctdspl2|CTDSPL2]]|0.452|
|[[:human genes:m:mlst8|MLST8]]|0.45|
|[[:human genes:n:nsd1|NSD1]]|0.449|
|[[:human genes:c:ccdc101|CCDC101]]|0.423|
|[[:human genes:r:rptor|RPTOR]]|0.42|
|[[:human genes:m:mef2c|MEF2C]]|0.416|
|[[:human genes:z:zmym2|ZMYM2]]|0.415|
|[[:human genes:z:zmiz1|ZMIZ1]]|0.412|
|[[:human genes:t:taf5l|TAF5L]]|0.402|
|[[:human genes:a:asb7|ASB7]]|0.401|
|[[:human genes:a:asxl2|ASXL2]]|0.4|
|[[:human genes:t:trmt10a|TRMT10A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3211
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM33 Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>