TRIM40

Entrez Summary: This gene encodes a member of the tripartite motif (TRIM) protein family. The encoded protein may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Feb 2014].
UniProt Summary: May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity. {ECO:0000269|PubMed:21474709}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

IkappaB kinase complex
protein neddylation
negative regulation of NIK/NF-kappaB signaling
negative regulation of protein localization to nucleus
negative regulation of NF-kappaB transcription factor activity
regulation of NIK/NF-kappaB signaling
negative regulation of cellular protein localization
regulation of protein localization to nucleus
negative regulation of protein catabolic process
negative regulation of DNA-binding transcription factor activity
negative regulation of cell growth
negative regulation of growth
negative regulation of catabolic process
regulation of protein catabolic process
regulation of cell growth
regulation of DNA-binding transcription factor activity
negative regulation of intracellular signal transduction
regulation of cellular protein localization
regulation of growth
protein modification by small protein conjugation
zinc ion binding
regulation of cellular localization
protein modification by small protein conjugation or removal
regulation of catabolic process
regulation of protein localization
negative regulation of protein metabolic process
negative regulation of molecular function
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
regulation of intracellular signal transduction