TRIM58 [The Human Chemical-Genetic Interaction Map Project]

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======= TRIM58 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM58
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 58
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25893|25893]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NG06|Q8NG06]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM58&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM58|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620527|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization. {ECO:0000269|PubMed:25241935}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
|zf-B box|
|SPRY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of erythrocyte enucleation|
|positive regulation of erythrocyte enucleation|
|regulation of nuclear migration along microtubule|
|positive regulation of cell maturation|
|regulation of organelle transport along microtubule|
|dynein heavy chain binding|
|regulation of cell maturation|
|dynein intermediate chain binding|
|positive regulation of erythrocyte differentiation|
|regulation of microtubule-based movement|
|regulation of erythrocyte differentiation|
|protein autoubiquitination|
|positive regulation of myeloid cell differentiation|
|positive regulation of hemopoiesis|
|ubiquitin protein ligase activity|
|regulation of microtubule-based process|
|regulation of myeloid cell differentiation|
|protein polyubiquitination|
|regulation of intracellular transport|
|regulation of hemopoiesis|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|positive regulation of cell development|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|molecular function|
|protein modification by small protein conjugation|
|zinc ion binding|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein modification by small protein conjugation or removal|
|regulation of cellular component movement|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|proteolysis|
|positive regulation of developmental process|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11372
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM58 Expression in NALM6 Cells: 2.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>