TRIM58

Gene Information

Official Symbol: TRIM58
Official Name: tripartite motif containing 58
Aliases and Previous Symbols: N/A
Entrez ID: 25893
UniProt: Q8NG06
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization. {ECO:0000269|PubMed:25241935}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11372
Expression level (log2 read counts): 2.46

Expression Distribution

zf-C3HC4
zf-B box
SPRY

regulation of erythrocyte enucleation
positive regulation of erythrocyte enucleation
regulation of nuclear migration along microtubule
positive regulation of cell maturation
regulation of organelle transport along microtubule
dynein heavy chain binding
regulation of cell maturation
dynein intermediate chain binding
positive regulation of erythrocyte differentiation
regulation of microtubule-based movement
regulation of erythrocyte differentiation
protein autoubiquitination
positive regulation of myeloid cell differentiation
positive regulation of hemopoiesis
ubiquitin protein ligase activity
regulation of microtubule-based process
regulation of myeloid cell differentiation
protein polyubiquitination
regulation of intracellular transport
regulation of hemopoiesis
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
positive regulation of cell development
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
molecular function
protein modification by small protein conjugation
zinc ion binding
cellular macromolecule catabolic process
regulation of cellular localization
regulation of cell development
positive regulation of cell differentiation
protein modification by small protein conjugation or removal
regulation of cellular component movement
macromolecule catabolic process
organonitrogen compound catabolic process
positive regulation of immune system process