TRIM62

Gene Information

Official Symbol: TRIM62
Official Name: tripartite motif containing 62
Aliases and Previous Symbols: N/A
Entrez ID: 55223
UniProt: Q9BVG3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2. {ECO:0000269|PubMed:23402750}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13381
Expression level (log2 read counts): 3.61

Expression Distribution

SPRY
zf-C3HC4
zf-B box

negative regulation of viral transcription
negative regulation of epithelial to mesenchymal transition
regulation of viral entry into host cell
regulation of viral release from host cell
regulation of viral transcription
interferon-gamma-mediated signaling pathway
regulation of epithelial to mesenchymal transition
negative regulation of viral process
regulation of viral life cycle
positive regulation of NF-kappaB transcription factor activity
cellular response to interferon-gamma
response to interferon-gamma
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of viral process
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
regulation of I-kappaB kinase/NF-kappaB signaling
ubiquitin-protein transferase activity
positive regulation of DNA-binding transcription factor activity
regulation of DNA-binding transcription factor activity
cytokine-mediated signaling pathway
protein ubiquitination
negative regulation of cell differentiation
innate immune response
protein modification by small protein conjugation
regulation of multi-organism process
zinc ion binding
negative regulation of developmental process
defense response to other organism
regulation of locomotion
protein modification by small protein conjugation or removal
cellular response to cytokine stimulus
positive regulation of intracellular signal transduction
response to cytokine
negative regulation of multicellular organismal process
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
positive regulation of signal transduction