TRIM9

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. {ECO:0000269|PubMed:20085810}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of SNARE complex assembly
negative regulation of vesicle fusion
negative regulation of calcium ion-dependent exocytosis
regulation of SNARE complex assembly
presynaptic cytosol
negative regulation of regulated secretory pathway
regulation of vesicle fusion
negative regulation of exocytosis
regulation of calcium ion-dependent exocytosis
synaptic vesicle exocytosis
SNARE binding
neurotransmitter secretion
signal release from synapse
synaptic vesicle cycle
synaptic vesicle
vesicle-mediated transport in synapse
negative regulation of protein complex assembly
regulation of regulated secretory pathway
signal release
neurotransmitter transport
negative regulation of secretion by cell
regulation of exocytosis
negative regulation of secretion
protein domain specific binding
ubiquitin-protein transferase activity
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
regulation of neurotransmitter levels
cytoskeleton
negative regulation of organelle organization
chemical synaptic transmission
dendrite
anterograde trans-synaptic signaling
trans-synaptic signaling
regulation of protein complex assembly
synaptic signaling
negative regulation of transport
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process