TRIP11 [The Human Chemical-Genetic Interaction Map Project]

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======= TRIP11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIP11
  * **<color #00a2e8>Official Name</color>**: thyroid hormone receptor interactor 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9321|9321]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15643|Q15643]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIP11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIP11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604505|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB- modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:9256431}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|outer acrosomal membrane|
|inner acrosomal membrane|
|inner ear receptor cell stereocilium organization|
|chondrocyte differentiation involved in endochondral bone morphogenesis|
|intraciliary transport involved in cilium assembly|
|inner ear receptor cell development|
|cartilage development involved in endochondral bone morphogenesis|
|inner ear receptor cell differentiation|
|intraciliary transport|
|mechanoreceptor differentiation|
|cis-Golgi network|
|microtubule-based protein transport|
|protein transport along microtubule|
|endochondral bone morphogenesis|
|ventricular septum development|
|chondrocyte differentiation|
|transport vesicle|
|cardiac septum development|
|bone morphogenesis|
|cardiac ventricle development|
|Golgi organization|
|transport along microtubule|
|cardiac chamber development|
|cartilage development|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|inner ear development|
|cilium|
|bone development|
|ear development|
|connective tissue development|
|skeletal system morphogenesis|
|protein-containing complex localization|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|microtubule-based movement|
|transcription coactivator activity|
|glycoprotein biosynthetic process|
|cilium assembly|
|cytoskeleton|
|cilium organization|
|glycoprotein metabolic process|
|nuclear speck|
|endomembrane system organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|transcription by RNA polymerase II|
|skeletal system development|
|heart development|
|sensory organ development|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|neuron projection development|
|microtubule-based process|
|organelle assembly|
|neuron development|
|circulatory system development|
|animal organ morphogenesis|
|Golgi apparatus|
|intracellular protein transport|
|neuron differentiation|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.74|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.83|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9847
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIP11 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>