TRIP11

Entrez Summary: This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010].
UniProt Summary: Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB- modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:9256431}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

outer acrosomal membrane
inner acrosomal membrane
inner ear receptor cell stereocilium organization
chondrocyte differentiation involved in endochondral bone morphogenesis
intraciliary transport involved in cilium assembly
inner ear receptor cell development
cartilage development involved in endochondral bone morphogenesis
inner ear receptor cell differentiation
intraciliary transport
mechanoreceptor differentiation
cis-Golgi network
microtubule-based protein transport
protein transport along microtubule
endochondral bone morphogenesis
ventricular septum development
chondrocyte differentiation
transport vesicle
cardiac septum development
bone morphogenesis
cardiac ventricle development
Golgi organization
transport along microtubule
cardiac chamber development
cartilage development
cytoskeleton-dependent intracellular transport
microtubule-based transport
inner ear development
cilium
bone development
ear development
connective tissue development
skeletal system morphogenesis
protein-containing complex localization
macromolecule glycosylation
protein glycosylation
glycosylation
microtubule-based movement
transcription coactivator activity
glycoprotein biosynthetic process
cilium assembly