TRPC4AP [The Human Chemical-Genetic Interaction Map Project]

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======= TRPC4AP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRPC4AP
  * **<color #00a2e8>Official Name</color>**: transient receptor potential cation channel subfamily C member 4 associated protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26133|26133]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TEL6|Q8TEL6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRPC4AP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRPC4AP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608430|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1. {ECO:0000269|PubMed:20551172}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3689|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hair follicle maturation|
|Cul4A-RING E3 ubiquitin ligase complex|
|phosphatase binding|
|hair follicle development|
|skin epidermis development|
|hair cycle process|
|molting cycle process|
|hair cycle|
|molting cycle|
|anatomical structure maturation|
|calcium ion transmembrane transport|
|developmental maturation|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|skin development|
|epidermis development|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|inorganic cation transmembrane transport|
|proteolysis involved in cellular protein catabolic process|
|cation transmembrane transport|
|cellular protein catabolic process|
|metal ion transport|
|inorganic ion transmembrane transport|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|cation transport|
|cellular macromolecule catabolic process|
|ion transmembrane transport|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|epithelium development|
|proteolysis|
|transmembrane transport|
|ion transport|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4764
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRPC4AP Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>