TRPC4AP

Official Symbol: TRPC4AP
Official Name: transient receptor potential cation channel subfamily C member 4 associated protein
Aliases and Previous Symbols: N/A
Entrez ID: 26133
UniProt: Q8TEL6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1. {ECO:0000269|PubMed:20551172}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hair follicle maturation
Cul4A-RING E3 ubiquitin ligase complex
phosphatase binding
hair follicle development
skin epidermis development
hair cycle process
molting cycle process
hair cycle
molting cycle
anatomical structure maturation
calcium ion transmembrane transport
developmental maturation
calcium ion transport
divalent metal ion transport
divalent inorganic cation transport
skin development
epidermis development
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
inorganic cation transmembrane transport
proteolysis involved in cellular protein catabolic process
cation transmembrane transport
cellular protein catabolic process
metal ion transport
inorganic ion transmembrane transport
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
cation transport
cellular macromolecule catabolic process
ion transmembrane transport
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
epithelium development
proteolysis
transmembrane transport
ion transport
tissue development