TRPT1

Entrez Summary: N/A
UniProt Summary: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1-2 cyclic phosphate. {ECO:0000305|PubMed:14504659}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

tRNA 2-phosphotransferase activity
tRNA splicing, via endonucleolytic cleavage and ligation
RNA splicing, via endonucleolytic cleavage and ligation
tRNA processing
tRNA metabolic process
ncRNA processing
RNA splicing
ncRNA metabolic process
molecular function
regulation of protein kinase activity
regulation of kinase activity
RNA processing
regulation of transferase activity
regulation of protein phosphorylation
regulation of phosphorylation
RNA metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
gene expression