TSN

Entrez Summary: N/A
UniProt Summary: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

production of siRNA involved in RNA interference
RNA interference
endoribonuclease activity
dsRNA processing
production of small RNA involved in gene silencing by RNA
posttranscriptional gene silencing by RNA
posttranscriptional gene silencing
RNA phosphodiester bond hydrolysis, endonucleolytic
gene silencing by RNA
single-stranded DNA binding
gene silencing
RNA phosphodiester bond hydrolysis
mRNA binding
DNA recombination
regulation of gene expression, epigenetic
protein-containing complex binding
nucleic acid phosphodiester bond hydrolysis
sequence-specific DNA binding
posttranscriptional regulation of gene expression
DNA metabolic process
RNA processing
identical protein binding
DNA binding
RNA metabolic process
negative regulation of gene expression
gene expression