TSPY1 [The Human Chemical-Genetic Interaction Map Project]

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======= TSPY1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TSPY1
  * **<color #00a2e8>Official Name</color>**: testis specific protein Y-linked 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7258|7258]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01534|Q01534]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TSPY1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TSPY1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/480100|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Many functional paralogs and pseudogenes of this gene are present in a cluster in humans, but only a single, nonfunctional orthologous gene is found in mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in sperm differentiation and proliferation. {ECO:0000269|PubMed:8923009}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gonadal mesoderm development|
|nucleosome assembly|
|mesoderm development|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|DNA packaging|
|protein-DNA complex assembly|
|gonad development|
|development of primary sexual characteristics|
|mesenchyme development|
|protein-DNA complex subunit organization|
|sex differentiation|
|DNA conformation change|
|reproductive structure development|
|reproductive system development|
|cellular component|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|chromatin organization|
|molecular function|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|multi-organism reproductive process|
|chromosome organization|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|tissue development|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.15|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.83|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.77|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.77|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.73|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.76|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.529|
|[[:human genes:p:polr2j3|POLR2J3]]|0.526|
|[[:human genes:p:prim1|PRIM1]]|0.524|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.52|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.515|
|[[:human genes:p:psma6|PSMA6]]|0.509|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.506|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.498|
|[[:human genes:r:rpl35|RPL35]]|0.493|
|[[:human genes:p:psmb4|PSMB4]]|0.492|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.483|
|[[:human genes:e:exosc8|EXOSC8]]|0.482|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.48|
|[[:human genes:r:rps2|RPS2]]|0.478|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.472|
|[[:human genes:u:upf1|UPF1]]|0.472|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.469|
|[[:human genes:c:col2a1|COL2A1]]|0.469|
|[[:human genes:r:rrp7a|RRP7A]]|0.467|
|[[:human genes:p:psmb2|PSMB2]]|0.466|
|[[:human genes:o:orc6|ORC6]]|0.457|
|[[:human genes:r:rad51|RAD51]]|0.457|
|[[:human genes:p:polr2d|POLR2D]]|0.457|
|[[:human genes:n:npipb5|NPIPB5]]|0.456|
|[[:human genes:p:pola2|POLA2]]|0.456|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.456|
|[[:human genes:p:psmd2|PSMD2]]|0.455|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.454|
|[[:human genes:c:cactin|CACTIN]]|0.453|
|[[:human genes:c:chd4|CHD4]]|0.452|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.451|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.451|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.451|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.45|
|[[:human genes:m:mt1e|MT1E]]|0.45|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.448|
|[[:human genes:m:myb|MYB]]|0.448|
|[[:human genes:c:ctage4|CTAGE4]]|0.447|
|[[:human genes:r:rpl6|RPL6]]|0.446|
|[[:human genes:t:tceb3c|TCEB3C]]|0.444|
|[[:human genes:c:cbwd3|CBWD3]]|0.441|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.44|
|[[:human genes:k:krt78|KRT78]]|0.439|
|[[:human genes:r:rpl9|RPL9]]|0.438|
|[[:human genes:c:cbwd5|CBWD5]]|0.436|
|[[:human genes:w:wdr75|WDR75]]|0.436|
|[[:human genes:h:hap1|HAP1]]|0.435|
|[[:human genes:p:psma7|PSMA7]]|0.434|
|[[:human genes:r:rrp15|RRP15]]|0.434|
|[[:human genes:p:psmc6|PSMC6]]|0.432|
|[[:human genes:t:timeless|TIMELESS]]|0.43|
|[[:human genes:p:psmc2|PSMC2]]|0.428|
|[[:human genes:n:nol12|NOL12]]|0.428|
|[[:human genes:r:rrn3|RRN3]]|0.426|
|[[:human genes:n:nbpf10|NBPF10]]|0.424|
|[[:human genes:f:fbxw9|FBXW9]]|0.423|
|[[:human genes:s:supt6h|SUPT6H]]|0.422|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.419|
|[[:human genes:c:c14orf93|C14orf93]]|0.419|
|[[:human genes:t:tfip11|TFIP11]]|0.418|
|[[:human genes:t:twistnb|TWISTNB]]|0.418|
|[[:human genes:u:uqcrh|UQCRH]]|0.417|
|[[:human genes:d:dtl|DTL]]|0.415|
|[[:human genes:c:cbwd6|CBWD6]]|0.413|
|[[:human genes:s:snrpa1|SNRPA1]]|0.413|
|[[:human genes:w:wdr87|WDR87]]|0.413|
|[[:human genes:t:tsg101|TSG101]]|0.411|
|[[:human genes:n:narfl|NARFL]]|0.41|
|[[:human genes:p:pola1|POLA1]]|0.409|
|[[:human genes:r:riok2|RIOK2]]|0.408|
|[[:human genes:c:copb1|COPB1]]|0.408|
|[[:human genes:l:lad1|LAD1]]|0.407|
|[[:human genes:h:hivep3|HIVEP3]]|0.407|
|[[:human genes:p:psmc4|PSMC4]]|0.405|
|[[:human genes:s:smg1|SMG1]]|0.405|
|[[:human genes:f:fam160a1|FAM160A1]]|0.405|
|[[:human genes:r:rps14|RPS14]]|0.405|
|[[:human genes:c:cdc6|CDC6]]|0.404|
|[[:human genes:o:orc1|ORC1]]|0.404|
|[[:human genes:d:ddx56|DDX56]]|0.404|
|[[:human genes:p:polr2a|POLR2A]]|0.403|
|[[:human genes:a:aatf|AATF]]|0.403|
|[[:human genes:s:sf3a3|SF3A3]]|0.402|
|[[:human genes:r:rpl17|RPL17]]|0.401|
|[[:human genes:o:ogfr|OGFR]]|0.401|
|[[:human genes:c:ccna2|CCNA2]]|0.4|
|[[:human genes:p:psmc5|PSMC5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2244
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TSPY1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>