TSPY1

Entrez Summary: The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Many functional paralogs and pseudogenes of this gene are present in a cluster in humans, but only a single, nonfunctional orthologous gene is found in mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
UniProt Summary: May be involved in sperm differentiation and proliferation. {ECO:0000269|PubMed:8923009}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hinokiflavone 12μM R08 exp487	-2.15
DABN 20μM R00 exp17	-1.83
Etoposide 1μM R00 exp19	-1.77
Salinomycin 3.5μM R08 exp521	-1.77
Pimelic-diphenylamide-106 5μM R00 exp28	-1.73
THZ531 0.225μM R08 exp444	1.76
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.42

Expression Distribution

gonadal mesoderm development
nucleosome assembly
mesoderm development
chromatin assembly
chromatin assembly or disassembly
nucleosome organization
DNA packaging
protein-DNA complex assembly
gonad development
development of primary sexual characteristics
mesenchyme development
protein-DNA complex subunit organization
sex differentiation
DNA conformation change
reproductive structure development
reproductive system development
cellular component
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
chromatin organization
molecular function
multicellular organismal reproductive process
sexual reproduction
cellular protein-containing complex assembly
multicellular organism reproduction
multi-organism reproductive process
chromosome organization
reproductive process
reproduction
protein-containing complex assembly
tissue development
protein-containing complex subunit organization