TSSC1 [The Human Chemical-Genetic Interaction Map Project]

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======= TSSC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIPR1
  * **<color #00a2e8>Official Name</color>**: EARP complex and GARP complex interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7260|7260]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53HC9|Q53HC9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TSSC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TSSC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608998|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of retrograde transport, endosome to Golgi|
|regulation of retrograde transport, endosome to Golgi|
|positive regulation of endocytic recycling|
|GARP complex|
|EARP complex|
|regulation of endocytic recycling|
|positive regulation of cytoplasmic transport|
|regulation of cytoplasmic transport|
|trans-Golgi network|
|positive regulation of intracellular transport|
|regulation of intracellular transport|
|regulation of vesicle-mediated transport|
|protein ubiquitination|
|protein modification by small protein conjugation|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-3.17|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-3.11|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.95|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.91|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.7|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.49|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.41|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.41|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.38|
|[[:results:exp539|42°C R08 exp539]]|-2.36|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.36|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.36|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-2.27|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2.19|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.19|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2.18|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.16|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-2.14|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.14|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.12|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.1|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-2.1|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.07|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.05|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.02|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-2|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.97|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.97|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.94|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.94|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.93|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.92|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.92|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.92|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.9|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.89|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.88|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.87|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.85|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.84|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.84|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.84|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.84|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.79|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.78|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.76|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.75|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.75|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.74|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.73|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.72|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.72|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gpr107|GPR107]]|0.495|
|[[:human genes:v:vps54|VPS54]]|0.483|
|[[:human genes:v:vps52|VPS52]]|0.446|
|[[:human genes:z:zfat|ZFAT]]|0.433|
|[[:human genes:s:scyl1|SCYL1]]|0.429|
|[[:human genes:j:jtb|JTB]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1526
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TSSC1 Expression in NALM6 Cells: 4.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>