TSSC1

Gene Information

Official Symbol: EIPR1
Official Name: EARP complex and GARP complex interacting protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 7260
UniProt: Q53HC9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bafilomycin-A1 0.009μM R08 exp454	-3.17
Amiloride 100μM R08 exp447	-3.11
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.95
Hippuristanol 0.12μM R08 exp488	-2.91
Vemurafenib 6.6μM R08 exp434	-2.7
B02 10μM R08 exp453	-2.49
Bisphenol A 100μM R06 exp269	-2.41
Tubacin 1.6μM R07 exp416	-2.41
BVD-523 15μM R02 exp67	-2.38
42°C R08 exp539	-2.36
Bisphenol F 50μM R08 exp457	-2.36
Tanespimycin 14μM R08 exp527	-2.36
Myriocin 25μM R06 exp293	-2.27
Rifampicin 30μM R08 exp430	-2.19
Thioridazine 5μM R08 exp530	-2.19
Wiskostatin 3μM R07 exp422	-2.18
Ibrutinib 10μM R08 exp442	-2.16
FK-506 5μM R07 exp358	-2.14
FTY720 3μM R08 exp483	-2.14
IU1-47 25μM R04 exp182	-2.12
Arsenic trioxide 60μM R08 exp449	-2.1
FK-506 30μM R07 exp359	-2.1
DABN 20μM R00 exp17	-2.07
Mubritinib 0.2μM R01 exp48	-2.05
Chloroquine 32μM R08 exp470	-2.02
Momordin-Ic 10μM R08 exp506	-2
Bleomycin 5μM R08 exp459	-1.97
BS-181 20μM R08 exp461	-1.97
Bortezomib 0.05μM R00 exp7	-1.94
Cerivastatin 0.15μM R05 exp226	-1.94
Tubastatin-A 2.5μM R07 exp417	-1.93
Ribavirin 10 to 15μM on day4 R04 exp160	-1.92
Salubrinal 20μM R07 exp399	-1.92
Wortmannin 0.5μM R00 exp37	-1.92
Trametinib 10μM R02 exp83	-1.9
Wortmannin 5μM R00 exp38	-1.89
Clomiphene 4.4μM R02 exp68	-1.88
Mubritinib 0.2μM R02 exp65	-1.87
Lapatinib 5μM R01 exp47	-1.85
Etoposide 0.3μM R05 exp199	-1.84
Monensin 0.3μM R08 exp507	-1.84
PU-H71 1μM R08 exp515	-1.84
Rapamycin 10μM R00 exp30	-1.84
Cannabidiol 20μM R08 exp466	-1.79
Doxorubicin 0.02μM R08 exp478	-1.78
QNZ 0.01μM R08 exp439	-1.76
CB-839 10μM R05 exp224	-1.75
Trimetrexate 0.03μM R08 exp535	-1.75
MLN-4924 0.2μM R00 exp21	-1.74
Rotenone 20μM R00 exp34	-1.73
CI-1040 9.5μM R08 exp472	-1.72
Etoposide 10μM R00 exp20	-1.72
Selumetinib 20μM R02 exp81	-1.71

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1526
Expression level (log2 read counts): 4.65

Expression Distribution

Gene	Correlation
GPR107	0.495
VPS54	0.483
VPS52	0.446
ZFAT	0.433
SCYL1	0.429
JTB	0.414

positive regulation of retrograde transport, endosome to Golgi
regulation of retrograde transport, endosome to Golgi
positive regulation of endocytic recycling
GARP complex
EARP complex
regulation of endocytic recycling
positive regulation of cytoplasmic transport
regulation of cytoplasmic transport
trans-Golgi network
positive regulation of intracellular transport
regulation of intracellular transport
regulation of vesicle-mediated transport
protein ubiquitination
protein modification by small protein conjugation
regulation of cellular localization
protein modification by small protein conjugation or removal
positive regulation of transport
regulation of transport