TTC21B

Entrez Summary: This gene encodes a member of TTC21 family, containing several tetratricopeptide repeat (TPR) domains. This protein is localized to the cilium axoneme, and may play a role in retrograde intraflagellar transport in cilia. Mutations in this gene are associated with various ciliopathies, nephronophthisis 12, and asphyxiating thoracic dystrophy 4. [provided by RefSeq, Oct 2011].
UniProt Summary: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Negatively modulates the SHH signal transduction (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Alda-1 10μM R06 exp262	-1.75
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.7

regulation of intraciliary retrograde transport
intraciliary transport particle A
forebrain dorsal/ventral pattern formation
intraciliary retrograde transport
forebrain regionalization
ventricular system development
regulation of microtubule-based movement
intraciliary transport involved in cilium assembly
ciliary tip
protein localization to cilium
intraciliary transport
protein transport along microtubule
microtubule-based protein transport
smoothened signaling pathway
regulation of smoothened signaling pathway
dorsal/ventral pattern formation
transport along microtubule
cytoskeleton-dependent intracellular transport
microtubule-based transport
cilium
regulation of microtubule-based process
regulation of intracellular protein transport
nuclear chromatin
protein-containing complex localization
microtubule-based movement
regionalization
cilium assembly
regulation of intracellular transport
cytoskeleton
cilium organization
forebrain development
pattern specification process
plasma membrane bounded cell projection assembly
cell projection assembly
regulation of cellular protein localization
microtubule-based process
regulation of plasma membrane bounded cell projection organization
regulation of protein transport
regulation of cell projection organization
protein localization to organelle