TTLL6

Entrez Summary: N/A
UniProt Summary: Polyglutamylase which preferentially modifies alpha- tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Generates long side-chains. Generates polyglutamylation of CGAS, leading to impair the DNA- binding activity of CGAS. {ECO:0000250|UniProtKB:A4Q9E8}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
MS094 2μM R03 exp136	1.9
UMK57 0.6μM R03 exp107	2.21

positive regulation of cilium movement
protein-glutamic acid ligase activity
protein polyglutamylation
microtubule severing
regulation of cilium movement
peptidyl-glutamic acid modification
regulation of microtubule-based movement
tubulin binding
microtubule bundle formation
ciliary basal body
regulation of microtubule-based process
microtubule
microtubule cytoskeleton organization
positive regulation of cellular component movement
microtubule-based process
peptidyl-amino acid modification
regulation of cellular component movement
cytoskeleton organization
ATP binding