TUB

Entrez Summary: This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. {ECO:0000250, ECO:0000269|PubMed:19837063}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intraciliary transport particle A binding
receptor localization to non-motile cilium
protein localization to photoreceptor outer segment
protein localization to ciliary membrane
protein localization to non-motile cilium
photoreceptor cell maintenance
protein localization to cilium
intraciliary transport
G protein-coupled receptor binding
microtubule-based protein transport
protein transport along microtubule
positive regulation of phagocytosis
retina homeostasis
regulation of phagocytosis
phagocytosis, recognition
retina development in camera-type eye
regulation of G protein-coupled receptor signaling pathway
sensory perception of sound
transport along microtubule
sensory perception of mechanical stimulus
cytoskeleton-dependent intracellular transport
microtubule-based transport
tissue homeostasis
cilium
protein localization to cell periphery
cell recognition
protein-containing complex localization
protein-containing complex binding
microtubule-based movement
camera-type eye development
multicellular organismal homeostasis
phagocytosis
anatomical structure homeostasis
eye development
visual system development
sensory system development
cilium organization
protein localization to membrane
sensory organ development
regulation of vesicle-mediated transport