TUBA1B [The Human Chemical-Genetic Interaction Map Project]

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======= TUBA1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBA1B
  * **<color #00a2e8>Official Name</color>**: tubulin alpha 1b
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10376|10376]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P68363|P68363]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBA1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBA1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602530|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tubulin|
|Tubulin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to interleukin-4|
|response to interleukin-4|
|cytoplasmic microtubule|
|double-stranded RNA binding|
|structural constituent of cytoskeleton|
|microtubule cytoskeleton|
|cytoskeleton-dependent intracellular transport|
|structural molecule activity|
|membrane raft|
|ubiquitin protein ligase binding|
|microtubule|
|GTPase activity|
|GTP binding|
|microtubule cytoskeleton organization|
|cell division|
|microtubule-based process|
|mitotic cell cycle|
|cellular response to cytokine stimulus|
|response to cytokine|
|cytoskeleton organization|
|cell cycle|
|intracellular transport|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.48|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.43|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.77|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.75|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.73|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.89|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|2.08|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|2.11|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|3.64|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|4.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:clasp1|CLASP1]]|0.499|
|[[:human genes:v:vbp1|VBP1]]|0.437|
|[[:human genes:p:pfdn5|PFDN5]]|0.432|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 35/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|2/26|
|breast|6/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 256
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBA1B Expression in NALM6 Cells: 10.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>