TUBA1B

Entrez Summary: N/A
UniProt Summary: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
S-trityl-L-cysteine 0.5μM R05 exp243	-2.48
Thimerosal 0.85μM R08 exp529	-2.43
BI-6727 0.0125μM R03 exp97	-1.77
LLY-283 2.6μM R06 exp290	-1.75
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.73
Phenformin 20μM R03 exp143	1.89
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	2.08
Tenofovir 10μM R07 exp405	2.11
Epothilone-B 0.0015μM R05 exp231	3.64
Taxol 0.004μM R03 exp103	4.28

Global Fraction of Cell Lines Where Essential: 35/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	2/26
breast	6/33
central nervous system	3/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	0/20
lung	1/75
lymphocyte	1/16
ovary	1/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	3/29
uterus	1/5

Expression Distribution

Tubulin
Tubulin C

cellular response to interleukin-4
response to interleukin-4
cytoplasmic microtubule
double-stranded RNA binding
structural constituent of cytoskeleton
microtubule cytoskeleton
cytoskeleton-dependent intracellular transport
structural molecule activity
membrane raft
ubiquitin protein ligase binding
microtubule
GTPase activity
GTP binding
microtubule cytoskeleton organization
cell division
microtubule-based process
mitotic cell cycle
cellular response to cytokine stimulus
response to cytokine
cytoskeleton organization
cell cycle
intracellular transport
establishment of localization in cell