TUBA8 [The Human Chemical-Genetic Interaction Map Project]

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======= TUBA8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBA8
  * **<color #00a2e8>Official Name</color>**: tubulin alpha 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51807|51807]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NY65|Q9NY65]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBA8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBA8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605742|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the alpha tubulin protein family. Alpha tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene are associated with polymicrogyria and optic nerve hypoplasia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tubulin|
|Tubulin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|structural constituent of cytoskeleton|
|microtubule cytoskeleton|
|microtubule|
|GTPase activity|
|GTP binding|
|microtubule cytoskeleton organization|
|microtubule-based process|
|mitotic cell cycle|
|cytoskeleton organization|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chd4|CHD4]]|0.525|
|[[:human genes:a:aqr|AQR]]|0.507|
|[[:human genes:s:supt5h|SUPT5H]]|0.487|
|[[:human genes:p:prim1|PRIM1]]|0.476|
|[[:human genes:v:vasn|VASN]]|0.473|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.472|
|[[:human genes:r:rps7|RPS7]]|0.472|
|[[:human genes:m:mt1e|MT1E]]|0.467|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.466|
|[[:human genes:o:orc1|ORC1]]|0.457|
|[[:human genes:r:rrp7a|RRP7A]]|0.457|
|[[:human genes:p:psmb4|PSMB4]]|0.453|
|[[:human genes:g:gar1|GAR1]]|0.452|
|[[:human genes:m:mfsd12|MFSD12]]|0.45|
|[[:human genes:c:cope|COPE]]|0.449|
|[[:human genes:p:psmb2|PSMB2]]|0.449|
|[[:human genes:t:twistnb|TWISTNB]]|0.447|
|[[:human genes:h:hinfp|HINFP]]|0.446|
|[[:human genes:s:snrpa1|SNRPA1]]|0.444|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.442|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.442|
|[[:human genes:d:dtl|DTL]]|0.441|
|[[:human genes:g:golga8o|GOLGA8O]]|0.438|
|[[:human genes:c:cln6|CLN6]]|0.438|
|[[:human genes:t:tceb3c|TCEB3C]]|0.438|
|[[:human genes:c:copg1|COPG1]]|0.437|
|[[:human genes:r:rpl6|RPL6]]|0.437|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.436|
|[[:human genes:i:iscu|ISCU]]|0.433|
|[[:human genes:c:copa|COPA]]|0.431|
|[[:human genes:p:polr2f|POLR2F]]|0.427|
|[[:human genes:t:timeless|TIMELESS]]|0.427|
|[[:human genes:g:golga8j|GOLGA8J]]|0.426|
|[[:human genes:c:cdc73|CDC73]]|0.425|
|[[:human genes:p:polr1a|POLR1A]]|0.424|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.421|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.421|
|[[:human genes:s:syt9|SYT9]]|0.42|
|[[:human genes:n:nupl1|NUPL1]]|0.42|
|[[:human genes:r:rps2|RPS2]]|0.42|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.419|
|[[:human genes:a:acsf2|ACSF2]]|0.418|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.417|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.417|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.417|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.417|
|[[:human genes:n:napa|NAPA]]|0.417|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.417|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.416|
|[[:human genes:f:fam160a1|FAM160A1]]|0.416|
|[[:human genes:c:ctage4|CTAGE4]]|0.415|
|[[:human genes:p:psap|PSAP]]|0.414|
|[[:human genes:a:aamp|AAMP]]|0.414|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.413|
|[[:human genes:i:ik|IK]]|0.412|
|[[:human genes:c:cgb2|CGB2]]|0.41|
|[[:human genes:d:ddx56|DDX56]]|0.41|
|[[:human genes:e:exosc5|EXOSC5]]|0.408|
|[[:human genes:e:egr2|EGR2]]|0.408|
|[[:human genes:r:rps12|RPS12]]|0.408|
|[[:human genes:u:utp3|UTP3]]|0.407|
|[[:human genes:g:golga8k|GOLGA8K]]|0.407|
|[[:human genes:a:akt1s1|AKT1S1]]|0.407|
|[[:human genes:c:cep192|CEP192]]|0.406|
|[[:human genes:t:tfip11|TFIP11]]|0.405|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.405|
|[[:human genes:u:upf1|UPF1]]|0.405|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.404|
|[[:human genes:p:pan2|PAN2]]|0.404|
|[[:human genes:t:ticrr|TICRR]]|0.404|
|[[:human genes:p:psma6|PSMA6]]|0.403|
|[[:human genes:c:c14orf93|C14orf93]]|0.403|
|[[:human genes:d:ddtl|DDTL]]|0.402|
|[[:human genes:d:disp2|DISP2]]|0.401|
|[[:human genes:z:znf830|ZNF830]]|0.401|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2703
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBA8 Expression in NALM6 Cells: 3.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>