TUBGCP2 [The Human Chemical-Genetic Interaction Map Project]

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======= TUBGCP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBGCP2
  * **<color #00a2e8>Official Name</color>**: tubulin gamma complex associated protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10844|10844]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BSJ2|Q9BSJ2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBGCP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBGCP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617817|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spc97 Spc98|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gamma-tubulin small complex|
|equatorial microtubule organizing center|
|microtubule nucleation by interphase microtubule organizing center|
|microtubule nucleation by microtubule organizing center|
|microtubule minus-end binding|
|gamma-tubulin complex|
|microtubule nucleation|
|gamma-tubulin binding|
|microtubule polymerization|
|microtubule polymerization or depolymerization|
|cytoplasmic microtubule|
|cytoplasmic microtubule organization|
|protein polymerization|
|spindle assembly|
|spindle pole|
|spindle organization|
|microtubule organizing center|
|meiotic cell cycle|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|centrosome|
|microtubule-based process|
|mitotic cell cycle|
|organelle assembly|
|cellular protein-containing complex assembly|
|cell cycle process|
|cytoskeleton organization|
|cell cycle|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.6|
|[[:results:exp539|42°C R08 exp539]]|-1.88|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.88|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.79|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.43|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 730/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|25/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|19/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 560
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBGCP2 Expression in NALM6 Cells: 6.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>