TUBGCP6 [The Human Chemical-Genetic Interaction Map Project]

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======= TUBGCP6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBGCP6
  * **<color #00a2e8>Official Name</color>**: tubulin gamma complex associated protein 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85378|85378]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96RT7|Q96RT7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBGCP6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBGCP6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610053|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. {ECO:0000269|PubMed:11694571}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spc97 Spc98|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gamma-tubulin small complex|
|equatorial microtubule organizing center|
|microtubule nucleation by interphase microtubule organizing center|
|microtubule nucleation by microtubule organizing center|
|gamma-tubulin ring complex|
|microtubule minus-end binding|
|gamma-tubulin complex|
|microtubule nucleation|
|gamma-tubulin binding|
|microtubule polymerization|
|microtubule polymerization or depolymerization|
|cytoplasmic microtubule organization|
|protein polymerization|
|spindle assembly|
|spindle pole|
|spindle organization|
|meiotic cell cycle|
|microtubule binding|
|microtubule|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|centrosome|
|microtubule-based process|
|mitotic cell cycle|
|organelle assembly|
|cellular protein-containing complex assembly|
|cell cycle process|
|cytoskeleton organization|
|cell cycle|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.14|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.81|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.73|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.7|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 121/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|3/28|
|bone|7/26|
|breast|8/33|
|central nervous system|7/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|2/16|
|kidney|4/21|
|liver|4/20|
|lung|12/75|
|lymphocyte|3/16|
|ovary|4/26|
|pancreas|4/24|
|peripheral nervous system|4/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|4/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1304
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBGCP6 Expression in NALM6 Cells: 6.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>