TUBGCP6

Entrez Summary: The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome. [provided by RefSeq, Jul 2008].
UniProt Summary: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. {ECO:0000269|PubMed:11694571}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 121/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	3/28
bone	7/26
breast	8/33
central nervous system	7/56
cervix	0/4
colorectal	2/17
esophagus	3/13
fibroblast	1/1
gastric	2/16
kidney	4/21
liver	4/20
lung	12/75
lymphocyte	3/16
ovary	4/26
pancreas	4/24
peripheral nervous system	4/16
plasma cell	4/15
prostate	1/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	4/29
uterus	2/5

Expression Distribution

gamma-tubulin small complex
equatorial microtubule organizing center
microtubule nucleation by interphase microtubule organizing center
microtubule nucleation by microtubule organizing center
gamma-tubulin ring complex
microtubule minus-end binding
gamma-tubulin complex
microtubule nucleation
gamma-tubulin binding
microtubule polymerization
microtubule polymerization or depolymerization
cytoplasmic microtubule organization
protein polymerization
spindle assembly
spindle pole
spindle organization
meiotic cell cycle
microtubule binding
microtubule
supramolecular fiber organization
microtubule cytoskeleton organization
centrosome
microtubule-based process
mitotic cell cycle
organelle assembly
cellular protein-containing complex assembly
cell cycle process
cytoskeleton organization
cell cycle
reproductive process
reproduction
protein-containing complex assembly
protein-containing complex subunit organization
membrane