TWF2

Entrez Summary: N/A
UniProt Summary: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of microvillus length
actin filament depolymerization
sequestering of actin monomers
regulation of cell projection size
regulation of microvillus organization
barbed-end actin filament capping
positive regulation of lamellipodium assembly
positive regulation of lamellipodium organization
actin monomer binding
myofibril
regulation of lamellipodium assembly
stereocilium
actin filament capping
negative regulation of actin filament depolymerization
protein depolymerization
regulation of lamellipodium organization
positive regulation of axon extension
actin polymerization or depolymerization
regulation of actin filament depolymerization
negative regulation of actin filament polymerization
protein kinase C binding
negative regulation of protein depolymerization
negative regulation of protein polymerization
cellular response to retinoic acid
negative regulation of protein complex disassembly
filopodium
maintenance of protein location in cell
phosphatidylinositol-4,5-bisphosphate binding
actin filament
regulation of protein depolymerization
positive regulation of axonogenesis
maintenance of location in cell
regulation of axon extension
positive regulation of plasma membrane bounded cell projection assembly
maintenance of protein location
response to retinoic acid
regulation of extent of cell growth
regulation of protein complex disassembly
growth cone
negative regulation of protein complex assembly