TXNDC8

Entrez Summary: N/A
UniProt Summary: May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Pyronaridine 1μM R06 exp295	-1.75
Nicotinate 1000μM R03 exp140	1.84

acrosome assembly
protein disulfide oxidoreductase activity
secretory granule organization
sperm flagellum
cell redox homeostasis
acrosomal vesicle
cellular component assembly involved in morphogenesis
spermatid development
spermatid differentiation
germ cell development
vesicle organization
cellular process involved in reproduction in multicellular organism
endomembrane system organization
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
organelle assembly
cellular component morphogenesis
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
anatomical structure formation involved in morphogenesis
cellular homeostasis
oxidation-reduction process
Golgi apparatus
multi-organism reproductive process
reproductive process
reproduction
homeostatic process
cell development