TXNIP [The Human Chemical-Genetic Interaction Map Project]

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======= TXNIP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TXNIP
  * **<color #00a2e8>Official Name</color>**: thioredoxin interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10628|10628]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H3M7|Q9H3M7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TXNIP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TXNIP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606599|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). {ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:21460850}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arrestin C|
|Arrestin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to tumor cell|
|response to tumor cell|
|negative regulation of cell division|
|enzyme inhibitor activity|
|platelet-derived growth factor receptor signaling pathway|
|response to progesterone|
|mitochondrial intermembrane space|
|protein import into nucleus|
|import into nucleus|
|response to hydrogen peroxide|
|response to estradiol|
|response to glucose|
|protein import|
|response to hexose|
|response to monosaccharide|
|response to calcium ion|
|protein localization to nucleus|
|regulation of cell division|
|response to carbohydrate|
|response to ketone|
|response to reactive oxygen species|
|response to mechanical stimulus|
|cellular response to biotic stimulus|
|nucleocytoplasmic transport|
|nuclear transport|
|keratinocyte differentiation|
|ubiquitin protein ligase binding|
|response to antibiotic|
|epidermal cell differentiation|
|response to steroid hormone|
|response to metal ion|
|skin development|
|response to oxidative stress|
|epidermis development|
|establishment of protein localization to organelle|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to inorganic substance|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|epithelial cell differentiation|
|positive regulation of cell death|
|enzyme linked receptor protein signaling pathway|
|protein localization to organelle|
|negative regulation of catalytic activity|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|response to hormone|
|response to organic cyclic compound|
|intracellular protein transport|
|response to drug|
|epithelium development|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|regulation of cell death|
|negative regulation of gene expression|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.9|
|[[:results:exp539|42°C R08 exp539]]|-2.03|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.97|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.87|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.84|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.71|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.71|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.72|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.72|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.73|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.78|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.84|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.89|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.09|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|2.15|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.22|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.29|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.33|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.38|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.47|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.89|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|4.16|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|4.37|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|4.53|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|8.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mlx|MLX]]|0.736|
|[[:human genes:m:mlxip|MLXIP]]|0.621|
|[[:human genes:m:msi2|MSI2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13986
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TXNIP Expression in NALM6 Cells: 6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>