TXNIP

Entrez Summary: N/A
UniProt Summary: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). {ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:21460850}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PU-H71 1μM R08 exp515	-2.9
42°C R08 exp539	-2.03
AICAR 240μM R03 exp116	-1.97
Aphidicolin 0.4μM R08 exp440	-1.87
Tanespimycin 14μM R08 exp527	-1.84
CFI-400945 25μM R08 exp469	-1.71
CB-839 10μM R05 exp224	1.71
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.72
Salubrinal 20μM R07 exp399	1.72
Cannabidiol 20μM R08 exp466	1.73
Betulinic acid 10 to 15μM on day4 R05 exp222	1.78
Cerivastatin 0.15μM R05 exp226	1.84
Pomalidomide 20μM R07 exp391	1.89
TRAIL 5ng/ml R00 exp35	2.09
Glyphosate 1000μM R06 exp283	2.15
CoCl2 18μM R07 exp346	2.22
FK-506 30μM R07 exp359	2.29
iCRT14 30μM R08 exp492	2.33
Wortmannin 0.5μM R00 exp37	2.38
Thapsigargin 0.005μM R07 exp407	2.47
UM0129480 7μM R02 exp85	2.89
Wortmannin 5μM R00 exp38	4.16
Oligomycin-A 2μM R00 exp25	4.37
Senexin-A 25μM R07 exp400	4.53
2-Deoxy-D-glucose 800μM R05 exp214	8.44

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Arrestin C
Arrestin N

cellular response to tumor cell
response to tumor cell
negative regulation of cell division
enzyme inhibitor activity
platelet-derived growth factor receptor signaling pathway
response to progesterone
mitochondrial intermembrane space
protein import into nucleus
import into nucleus
response to hydrogen peroxide
response to estradiol
response to glucose
protein import
response to hexose
response to monosaccharide
response to calcium ion
protein localization to nucleus
regulation of cell division
response to carbohydrate
response to ketone
response to reactive oxygen species
response to mechanical stimulus
cellular response to biotic stimulus
nucleocytoplasmic transport
nuclear transport
keratinocyte differentiation
ubiquitin protein ligase binding
response to antibiotic
epidermal cell differentiation
response to steroid hormone
response to metal ion
skin development
response to oxidative stress
epidermis development
establishment of protein localization to organelle
response to toxic substance
transmembrane receptor protein tyrosine kinase signaling pathway
response to inorganic substance
positive regulation of apoptotic process
positive regulation of programmed cell death