TYK2
Gene Information
- Official Symbol: TYK2
- Official Name: tyrosine kinase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 7297
- UniProt: P29597
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008].
- UniProt Summary: Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. {ECO:0000269|PubMed:7526154}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4388
- Expression level (log2 read counts): 7.45
TYK2 Expression in NALM6 Cells: 7.45
