TYMP

Entrez Summary: This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012].
UniProt Summary: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. {ECO:0000269|PubMed:1590793}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

pyrimidine-nucleoside phosphorylase activity
thymidine phosphorylase activity
phosphorylase activity
regulation of gastric motility
pyrimidine nucleoside salvage
pyrimidine-containing compound salvage
nucleoside salvage
pyrimidine nucleoside biosynthetic process
regulation of transmission of nerve impulse
mitochondrial genome maintenance
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
nucleoside catabolic process
cellular metabolic compound salvage
pyrimidine nucleoside metabolic process
nucleoside biosynthetic process
regulation of digestive system process
regulation of myelination
glycosyl compound biosynthetic process
nucleobase metabolic process
pyrimidine-containing compound catabolic process
glycosyl compound catabolic process
nucleobase-containing small molecule catabolic process
pyrimidine-containing compound biosynthetic process
nucleobase-containing small molecule biosynthetic process
pyrimidine-containing compound metabolic process
nucleoside metabolic process
glycosyl compound metabolic process
regulation of nervous system process
growth factor activity
carbohydrate derivative catabolic process
angiogenesis
nucleobase-containing compound catabolic process
blood vessel morphogenesis
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
mitochondrion organization
aromatic compound catabolic process
organic cyclic compound catabolic process