TYRP1

Entrez Summary: This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009].
UniProt Summary: Catalyzes the oxidation of 5,6-dihydroxyindole-2- carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity). {ECO:0000250|UniProtKB:P07147, ECO:0000269|PubMed:28661582, ECO:0000305|PubMed:16704458, ECO:0000305|PubMed:22556244, ECO:0000305|PubMed:23504663}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

acetoacetic acid metabolic process
monophenol monooxygenase activity
intracellular vesicle
positive regulation of melanin biosynthetic process
positive regulation of secondary metabolite biosynthetic process
regulation of melanin biosynthetic process
regulation of secondary metabolite biosynthetic process
ketone body metabolic process
melanin biosynthetic process
regulation of secondary metabolic process
melanosome membrane
melanin metabolic process
short-chain fatty acid metabolic process
secondary metabolite biosynthetic process
melanocyte differentiation
melanosome organization
pigment granule organization
pigment cell differentiation
clathrin-coated endocytic vesicle membrane
phenol-containing compound biosynthetic process
developmental pigmentation
cellular pigmentation
pigment biosynthetic process
secondary metabolic process
pigment metabolic process
phenol-containing compound metabolic process
pigmentation
melanosome
oxidoreductase activity
fatty acid derivative metabolic process
organic hydroxy compound biosynthetic process
endosome membrane
vesicle organization
fatty acid metabolic process
generation of precursor metabolites and energy
organic hydroxy compound metabolic process
protein heterodimerization activity
drug metabolic process
monocarboxylic acid metabolic process
protein homodimerization activity