UBA1 [The Human Chemical-Genetic Interaction Map Project]

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======= UBA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBA1
  * **<color #00a2e8>Official Name</color>**: ubiquitin like modifier activating enzyme 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7317|7317]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22314|P22314]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/314370|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation- induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UBA e1 thiolCys|
|UBA e1 C|
|ThiF|
|UBACT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin activating enzyme activity|
|rough endoplasmic reticulum membrane|
|desmosome|
|heterochromatin|
|endosome membrane|
|lysosomal membrane|
|protein ubiquitination|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|protein modification by small protein conjugation or removal|
|mitochondrion|
|RNA binding|
|ATP binding|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.55|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.34|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.27|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.18|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.07|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.02|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.93|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.88|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.86|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.85|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.85|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.76|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.74|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.72|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.71|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.7|
|[[:results:exp483|FTY720 3μM R08 exp483]]|1.7|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.71|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.72|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.73|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.8|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.82|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.83|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.89|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2.05|
|[[:results:exp132|Metformin 40μM R03 exp132]]|2.5|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 694/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|26/26|
|bone|26/26|
|breast|30/30|
|central nervous system|49/49|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/11|
|fibroblast|1/1|
|gastric|14/14|
|kidney|18/18|
|liver|19/19|
|lung|72/72|
|lymphocyte|16/16|
|ovary|25/25|
|pancreas|22/22|
|peripheral nervous system|15/15|
|plasma cell|12/12|
|prostate|1/1|
|skin|20/20|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/28|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 388
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBA1 Expression in NALM6 Cells: 8.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>