UBA2

Entrez Summary: N/A
UniProt Summary: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 678/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	24/28
blood	24/28
bone	25/26
breast	31/33
central nervous system	54/56
cervix	4/4
colorectal	16/17
esophagus	10/13
fibroblast	1/1
gastric	15/16
kidney	21/21
liver	16/20
lung	68/75
lymphocyte	16/16
ovary	24/26
pancreas	22/24
peripheral nervous system	15/16
plasma cell	13/15
prostate	1/1
skin	21/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	28/29
uterus	4/5

Expression Distribution

SUMO activating enzyme activity
SUMO activating enzyme complex
small protein activating enzyme binding
ubiquitin-like protein conjugating enzyme binding
SUMO binding
enzyme activator activity
transferase activity
protein sumoylation
magnesium ion binding
peptidyl-lysine modification
transcription factor binding
protein heterodimerization activity
protein modification by small protein conjugation
peptidyl-amino acid modification
protein modification by small protein conjugation or removal
positive regulation of catalytic activity
ATP binding
positive regulation of molecular function