UBA3 [The Human Chemical-Genetic Interaction Map Project]

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======= UBA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBA3
  * **<color #00a2e8>Official Name</color>**: ubiquitin like modifier activating enzyme 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9039|9039]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TBC4|Q8TBC4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603172|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:9694792}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UBA e1 thiolCys|
|E2 bind|
|ThiF|
|UBACT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NEDD8 activating enzyme activity|
|endomitotic cell cycle|
|NEDD8 transferase activity|
|protein neddylation|
|nuclear receptor binding|
|post-translational protein modification|
|protein heterodimerization activity|
|protein-containing complex|
|mitotic cell cycle|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
|identical protein binding|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.86|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.59|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-2.55|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.52|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.52|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.5|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.49|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.3|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-2.28|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.23|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-2.17|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-2.17|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.17|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.11|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-2.08|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.07|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.02|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.99|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.97|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.95|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.91|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.91|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.89|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.88|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.88|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.88|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.87|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.87|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.82|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.81|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.77|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.74|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.73|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.73|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.72|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.77|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.8|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.93|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.94|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.74|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nae1|NAE1]]|0.632|
|[[:human genes:u:ube2m|UBE2M]]|0.62|
|[[:human genes:t:thg1l|THG1L]]|0.56|
|[[:human genes:a:alg1|ALG1]]|0.548|
|[[:human genes:p:pmm2|PMM2]]|0.528|
|[[:human genes:g:gmppb|GMPPB]]|0.521|
|[[:human genes:d:dpagt1|DPAGT1]]|0.512|
|[[:human genes:t:triap1|TRIAP1]]|0.508|
|[[:human genes:t:trmt5|TRMT5]]|0.506|
|[[:human genes:g:glmn|GLMN]]|0.501|
|[[:human genes:r:rnmt|RNMT]]|0.498|
|[[:human genes:h:hars|HARS]]|0.496|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.495|
|[[:human genes:h:hspd1|HSPD1]]|0.489|
|[[:human genes:g:gfpt1|GFPT1]]|0.488|
|[[:human genes:a:adsl|ADSL]]|0.485|
|[[:human genes:a:atp5j|ATP5J]]|0.484|
|[[:human genes:e:eny2|ENY2]]|0.484|
|[[:human genes:u:uap1|UAP1]]|0.481|
|[[:human genes:p:plaa|PLAA]]|0.476|
|[[:human genes:r:rptor|RPTOR]]|0.474|
|[[:human genes:a:atxn10|ATXN10]]|0.473|
|[[:human genes:r:rtcb|RTCB]]|0.473|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.468|
|[[:human genes:w:wdr59|WDR59]]|0.467|
|[[:human genes:a:atic|ATIC]]|0.465|
|[[:human genes:a:apaf1|APAF1]]|0.462|
|[[:human genes:u:uhrf1|UHRF1]]|0.461|
|[[:human genes:c:csnk2b|CSNK2B]]|0.459|
|[[:human genes:n:nbn|NBN]]|0.457|
|[[:human genes:v:vezt|VEZT]]|0.455|
|[[:human genes:d:dr1|DR1]]|0.454|
|[[:human genes:t:ttc4|TTC4]]|0.451|
|[[:human genes:s:slc25a19|SLC25A19]]|0.45|
|[[:human genes:p:ppp6c|PPP6C]]|0.448|
|[[:human genes:o:oraov1|ORAOV1]]|0.444|
|[[:human genes:s:srp14|SRP14]]|0.443|
|[[:human genes:c:cct7|CCT7]]|0.441|
|[[:human genes:l:lsmd1|LSMD1]]|0.439|
|[[:human genes:b:btaf1|BTAF1]]|0.439|
|[[:human genes:m:meaf6|MEAF6]]|0.437|
|[[:human genes:p:polr3h|POLR3H]]|0.435|
|[[:human genes:b:bak1|BAK1]]|0.435|
|[[:human genes:h:hspa9|HSPA9]]|0.434|
|[[:human genes:c:casp9|CASP9]]|0.432|
|[[:human genes:u:ube2l3|UBE2L3]]|0.432|
|[[:human genes:w:wdr24|WDR24]]|0.432|
|[[:human genes:m:med16|MED16]]|0.431|
|[[:human genes:y:yars|YARS]]|0.43|
|[[:human genes:h:hccs|HCCS]]|0.427|
|[[:human genes:a:alg6|ALG6]]|0.427|
|[[:human genes:p:ppp4c|PPP4C]]|0.426|
|[[:human genes:t:tti1|TTI1]]|0.426|
|[[:human genes:t:tsen34|TSEN34]]|0.426|
|[[:human genes:c:cars|CARS]]|0.425|
|[[:human genes:f:fh|FH]]|0.424|
|[[:human genes:m:mars|MARS]]|0.423|
|[[:human genes:r:rabggtb|RABGGTB]]|0.422|
|[[:human genes:t:thoc6|THOC6]]|0.42|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.42|
|[[:human genes:n:nup50|NUP50]]|0.42|
|[[:human genes:s:sec16a|SEC16A]]|0.418|
|[[:human genes:d:dohh|DOHH]]|0.418|
|[[:human genes:r:rpp21|RPP21]]|0.417|
|[[:human genes:a:alg2|ALG2]]|0.416|
|[[:human genes:d:ddx20|DDX20]]|0.415|
|[[:human genes:t:trnt1|TRNT1]]|0.415|
|[[:human genes:m:mapk14|MAPK14]]|0.413|
|[[:human genes:d:dolk|DOLK]]|0.413|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.413|
|[[:human genes:s:slc25a26|SLC25A26]]|0.413|
|[[:human genes:p:ppcs|PPCS]]|0.412|
|[[:human genes:n:nxt1|NXT1]]|0.412|
|[[:human genes:g:gemin6|GEMIN6]]|0.411|
|[[:human genes:t:tti2|TTI2]]|0.41|
|[[:human genes:k:kctd5|KCTD5]]|0.409|
|[[:human genes:m:march5|MARCH5]]|0.407|
|[[:human genes:g:gemin8|GEMIN8]]|0.404|
|[[:human genes:a:aars|AARS]]|0.404|
|[[:human genes:r:rfk|RFK]]|0.403|
|[[:human genes:c:cep57|CEP57]]|0.402|
|[[:human genes:g:gnb1l|GNB1L]]|0.401|
|[[:human genes:p:pelo|PELO]]|0.401|
|[[:human genes:u:ube2g2|UBE2G2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 478/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|22/28|
|blood|16/28|
|bone|22/26|
|breast|23/33|
|central nervous system|32/56|
|cervix|4/4|
|colorectal|12/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|15/21|
|liver|10/20|
|lung|49/75|
|lymphocyte|6/16|
|ovary|14/26|
|pancreas|20/24|
|peripheral nervous system|12/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|20/22|
|urinary tract|18/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 428
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBA3 Expression in NALM6 Cells: 6.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>