UBA6 [The Human Chemical-Genetic Interaction Map Project]

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======= UBA6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBA6
  * **<color #00a2e8>Official Name</color>**: ubiquitin like modifier activating enzyme 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55236|55236]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A0AVT1|A0AVT1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBA6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBA6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611361|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UBA e1 thiolCys|
|UBA e1 C|
|ThiF|
|UBACT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|FAT10 activating enzyme activity|
|amygdala development|
|ubiquitin activating enzyme activity|
|dendritic spine development|
|hippocampus development|
|dendrite development|
|limbic system development|
|learning|
|pallium development|
|locomotory behavior|
|telencephalon development|
|learning or memory|
|cognition|
|forebrain development|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|behavior|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|neuron projection development|
|protein catabolic process|
|protein ubiquitination|
|brain development|
|protein modification by small protein conjugation|
|head development|
|neuron development|
|cellular macromolecule catabolic process|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|neuron differentiation|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|proteolysis|
|nervous system process|
|ATP binding|
|generation of neurons|
|neurogenesis|
|cell development|
|organic substance catabolic process|
|cellular catabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.87|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.83|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.73|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.77|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.86|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.87|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.02|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.13|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.14|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.35|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.58|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.78|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|3.12|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|3.22|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|5.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:birc6|BIRC6]]|0.639|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6848
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBA6 Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>