UBE2C [The Human Chemical-Genetic Interaction Map Project]

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======= UBE2C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE2C
  * **<color #00a2e8>Official Name</color>**: ubiquitin conjugating enzyme E2 C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11065|11065]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00762|O00762]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE2C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE2C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605574|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. {ECO:0000269|PubMed:15558010, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27259151}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UQ con|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|free ubiquitin chain polymerization|
|positive regulation of exit from mitosis|
|ubiquitin recycling|
|positive regulation of ubiquitin protein ligase activity|
|exit from mitosis|
|regulation of exit from mitosis|
|anaphase-promoting complex|
|regulation of ubiquitin protein ligase activity|
|ubiquitin-like protein ligase binding|
|protein K11-linked ubiquitination|
|positive regulation of ubiquitin-protein transferase activity|
|ubiquitin conjugating enzyme activity|
|regulation of ubiquitin-protein transferase activity|
|positive regulation of mitotic nuclear division|
|protein K48-linked ubiquitination|
|positive regulation of nuclear division|
|positive regulation of mitotic cell cycle phase transition|
|anaphase-promoting complex-dependent catabolic process|
|protein polymerization|
|positive regulation of cell cycle phase transition|
|ubiquitin ligase complex|
|positive regulation of protein ubiquitination|
|positive regulation of protein modification by small protein conjugation or removal|
|mitotic nuclear division|
|positive regulation of mitotic cell cycle|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|regulation of protein ubiquitination|
|regulation of protein modification by small protein conjugation or removal|
|ubiquitin-protein transferase activity|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|nuclear division|
|positive regulation of cell cycle process|
|protein polyubiquitination|
|organelle fission|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|mitotic cell cycle|
|protein catabolic process|
|protein ubiquitination|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|cellular protein-containing complex assembly|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|positive regulation of catalytic activity|
|ATP binding|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-3.52|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-3.36|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.61|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.45|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.37|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.31|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.27|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.21|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.06|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.03|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.94|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.87|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.83|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:ube2s|UBE2S]]|0.566|
|[[:human genes:s:ska1|SKA1]]|0.498|
|[[:human genes:a:anapc15|ANAPC15]]|0.43|
|[[:human genes:s:spag5|SPAG5]]|0.417|
|[[:human genes:a:anapc13|ANAPC13]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 23/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|2/26|
|breast|1/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|3/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2699
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE2C Expression in NALM6 Cells: 6.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>