UBE2C

Gene Information

Official Symbol: UBE2C
Official Name: ubiquitin conjugating enzyme E2 C
Aliases and Previous Symbols: N/A
Entrez ID: 11065
UniProt: O00762
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. {ECO:0000269|PubMed:15558010, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27259151}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Apcin 50 to 100μM on day4 R04 exp176	-3.52
Apcin 25μM plus proTAME 2μM R04 exp177	-3.36
MLN-4924 0.2μM R00 exp21	-2.61
Sulforaphane 9μM R08 exp526 no dilution day6	-2.45
BI-6727 0.0125μM R03 exp97	-2.37
GSK461364A 0.005μM R03 exp125	-2.31
BI-2536 0.0042μM R03 exp95	-2.27
proTAME 5μM R04 exp187	-2.21
LB-100 2μM R05 exp210	-2.06
GSK626616 14μM R08 exp485	-2.03
Nutlin-3A 1.6μM R06 exp294	-1.94
Temozolomide 200μM R04 exp189	-1.87
Demecolcine 0.03μM R05 exp228	-1.83
Colchicine 0.009μM R05 exp215	-1.77

Global Fraction of Cell Lines Where Essential: 23/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	2/26
breast	1/33
central nervous system	4/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	3/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	3/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 2699
Expression level (log2 read counts): 6.06

Expression Distribution

Gene	Correlation
UBE2S	0.566
SKA1	0.498
ANAPC15	0.43
SPAG5	0.417
ANAPC13	0.408

free ubiquitin chain polymerization
positive regulation of exit from mitosis
ubiquitin recycling
positive regulation of ubiquitin protein ligase activity
exit from mitosis
regulation of exit from mitosis
anaphase-promoting complex
regulation of ubiquitin protein ligase activity
ubiquitin-like protein ligase binding
protein K11-linked ubiquitination
positive regulation of ubiquitin-protein transferase activity
ubiquitin conjugating enzyme activity
regulation of ubiquitin-protein transferase activity
positive regulation of mitotic nuclear division
protein K48-linked ubiquitination
positive regulation of nuclear division
positive regulation of mitotic cell cycle phase transition
anaphase-promoting complex-dependent catabolic process
protein polymerization
positive regulation of cell cycle phase transition
ubiquitin ligase complex
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
mitotic nuclear division
positive regulation of mitotic cell cycle
regulation of mitotic nuclear division
regulation of nuclear division
regulation of protein ubiquitination
regulation of protein modification by small protein conjugation or removal
ubiquitin-protein transferase activity
mitotic cell cycle phase transition
cell cycle phase transition
nuclear division
positive regulation of cell cycle process
protein polyubiquitination
organelle fission
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
positive regulation of cell cycle
regulation of mitotic cell cycle phase transition