UBE2D1

Gene Information

Official Symbol: UBE2D1
Official Name: ubiquitin conjugating enzyme E2 D1
Aliases and Previous Symbols: N/A
Entrez ID: 7321
UniProt: P51668
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). {ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:22496338}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18442
Expression level (log2 read counts): 4.14

Expression Distribution

positive regulation of protein polyubiquitination
regulation of protein polyubiquitination
TRIF-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
ubiquitin conjugating enzyme activity
protein K48-linked ubiquitination
establishment of protein localization to peroxisome
protein targeting to peroxisome
protein localization to peroxisome
peroxisomal transport
peroxisome organization
anaphase-promoting complex-dependent catabolic process
BMP signaling pathway
toll-like receptor signaling pathway
response to BMP
cellular response to BMP stimulus
ubiquitin ligase complex
positive regulation of protein ubiquitination
pattern recognition receptor signaling pathway
positive regulation of protein modification by small protein conjugation or removal
transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of protein ubiquitination
regulation of protein modification by small protein conjugation or removal
innate immune response-activating signal transduction
ubiquitin-protein transferase activity
activation of innate immune response
protein deubiquitination
ubiquitin protein ligase binding
protein modification by small protein removal
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of innate immune response
proteasomal protein catabolic process
protein targeting
positive regulation of response to biotic stimulus
regulation of mitotic cell cycle phase transition
establishment of protein localization to organelle
regulation of cell cycle phase transition
regulation of innate immune response
positive regulation of defense response