UBE2Z

Entrez Summary: N/A
UniProt Summary: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. {ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000269|PubMed:17464193, ECO:0000269|PubMed:17597759}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 10/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cysteine-type endopeptidase inhibitor activity
ubiquitin conjugating enzyme activity
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
positive regulation of apoptotic process
positive regulation of programmed cell death
protein catabolic process
protein ubiquitination
positive regulation of cell death
regulation of proteolysis
protein modification by small protein conjugation
negative regulation of catalytic activity
negative regulation of apoptotic process
cellular macromolecule catabolic process
negative regulation of programmed cell death
apoptotic process
protein modification by small protein conjugation or removal
negative regulation of cell death
negative regulation of cellular protein metabolic process
macromolecule catabolic process
programmed cell death
organonitrogen compound catabolic process
cell death
negative regulation of protein metabolic process
negative regulation of molecular function
proteolysis
regulation of hydrolase activity
ATP binding
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death