UBR3

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610). {ECO:0000250|UniProtKB:Q5U430, ECO:0000269|PubMed:27331610}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ubiquitin-dependent protein catabolic process via the N-end rule pathway
olfactory behavior
suckling behavior
chemosensory behavior
multi-organism behavior
feeding behavior
ubiquitin ligase complex
ubiquitin protein ligase activity
ubiquitin-protein transferase activity
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
in utero embryonic development
sensory perception of smell
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
sensory perception of chemical stimulus
modification-dependent macromolecule catabolic process
behavior
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
chordate embryonic development
embryo development ending in birth or egg hatching
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
zinc ion binding
cellular macromolecule catabolic process
sensory perception
embryo development
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
nervous system process
organic substance catabolic process
cellular catabolic process
system process