UBXN2B

Entrez Summary: N/A
UniProt Summary: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. {ECO:0000269|PubMed:17141156}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

UBX
SEP

negative regulation of protein localization to centrosome
positive regulation of mitotic centrosome separation
regulation of mitotic centrosome separation
regulation of protein localization to centrosome
positive regulation of centrosome cycle
spindle pole centrosome
nuclear envelope reassembly
establishment of mitotic spindle orientation
establishment of mitotic spindle localization
establishment of spindle orientation
establishment of spindle localization
spindle localization
positive regulation of mitotic nuclear division
nuclear envelope organization
regulation of centrosome cycle
autophagosome assembly
autophagosome organization
positive regulation of nuclear division
ubiquitin binding
microtubule cytoskeleton organization involved in mitosis
negative regulation of cellular protein localization
establishment of cell polarity
vacuole organization
membrane fusion
Golgi organization
nucleus organization
positive regulation of mitotic cell cycle
macroautophagy
regulation of mitotic nuclear division
regulation of microtubule cytoskeleton organization
regulation of nuclear division
establishment or maintenance of cell polarity
positive regulation of cytoskeleton organization
regulation of microtubule-based process
autophagy
process utilizing autophagic mechanism
positive regulation of cell cycle process
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
establishment of organelle localization