UGGT2

Entrez Summary: N/A
UniProt Summary: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Glyco transf 8
UDP-g GGTase

UDP-glucose:glycoprotein glucosyltransferase activity
UDP-glucosylation
UDP-glucose metabolic process
ER-associated misfolded protein catabolic process
endoplasmic reticulum mannose trimming
protein demannosylation
protein alpha-1,2-demannosylation
endoplasmic reticulum quality control compartment
cellular response to misfolded protein
response to misfolded protein
protein quality control for misfolded or incompletely synthesized proteins
protein deglycosylation
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
nucleotide-sugar metabolic process
endoplasmic reticulum-Golgi intermediate compartment
protein N-linked glycosylation
ERAD pathway
unfolded protein binding
cellular response to topologically incorrect protein
response to topologically incorrect protein
response to endoplasmic reticulum stress
macromolecule glycosylation
protein glycosylation
glycosylation
endoplasmic reticulum lumen
glycoprotein biosynthetic process
proteasomal protein catabolic process
glycoprotein metabolic process
nucleobase-containing small molecule metabolic process
proteolysis involved in cellular protein catabolic process
protein-containing complex
cellular protein catabolic process
carbohydrate derivative biosynthetic process
protein catabolic process
peptidyl-amino acid modification
cellular macromolecule catabolic process
response to organonitrogen compound
endoplasmic reticulum
carbohydrate derivative metabolic process