UGT2B17
Gene Information
- Official Symbol: UGT2B17
- Official Name: UDP glucuronosyltransferase family 2 member B17
- Aliases and Previous Symbols: N/A
- Entrez ID: 7367
- UniProt: O75795
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.[provided by RefSeq, Apr 2010].
- UniProt Summary: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16302
- Expression level (log2 read counts): -5.6
UGT2B17 Expression in NALM6 Cells: -5.6
