ULBP3

Gene Information

Official Symbol: ULBP3
Official Name: UL16 binding protein 3
Aliases and Previous Symbols: N/A
Entrez ID: 79465
UniProt: Q9BZM4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. {ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11754823, ECO:0000269|PubMed:11777960}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7197
Expression level (log2 read counts): 2.61

Expression Distribution

natural killer cell lectin-like receptor binding
susceptibility to natural killer cell mediated cytotoxicity
T cell mediated cytotoxicity
natural killer cell mediated cytotoxicity
natural killer cell mediated immunity
positive regulation of natural killer cell mediated cytotoxicity
anchored component of plasma membrane
positive regulation of natural killer cell mediated immunity
leukocyte mediated cytotoxicity
T cell mediated immunity
regulation of natural killer cell mediated cytotoxicity
regulation of natural killer cell mediated immunity
positive regulation of leukocyte mediated cytotoxicity
natural killer cell activation
positive regulation of cell killing
regulation of leukocyte mediated cytotoxicity
cell killing
regulation of cell killing
positive regulation of lymphocyte mediated immunity
positive regulation of leukocyte mediated immunity
regulation of lymphocyte mediated immunity
regulation of leukocyte mediated immunity
positive regulation of immune effector process
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
positive regulation of innate immune response
positive regulation of response to biotic stimulus
lymphocyte activation
external side of plasma membrane
regulation of innate immune response
regulation of immune effector process
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
positive regulation of response to external stimulus
adaptive immune response
viral process
regulation of defense response
innate immune response
leukocyte mediated immunity