UNC13C

Entrez Summary: N/A
UniProt Summary: May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Cisplatin 0.35μM R06 exp273	-1.8
D-Fructose 10000μM R06 exp279	-1.73

dense core granule priming
neuronal dense core vesicle exocytosis
negative regulation of synaptic plasticity
presynaptic dense core vesicle exocytosis
dense core granule exocytosis
synaptic vesicle docking
diacylglycerol binding
synaptic vesicle maturation
presynaptic active zone cytoplasmic component
synaptic vesicle priming
parallel fiber to Purkinje cell synapse
calcium ion-regulated exocytosis of neurotransmitter
calyx of Held
syntaxin-1 binding
synaptic transmission, glutamatergic
presynaptic active zone
calcium-ion regulated exocytosis
vesicle docking involved in exocytosis
neuromuscular junction development
terminal bouton
vesicle docking
synaptic vesicle exocytosis
exocytic process
synaptic vesicle membrane
presynaptic membrane
neuromuscular junction
neurotransmitter secretion
signal release from synapse
phospholipid binding
synaptic vesicle cycle
vesicle-mediated transport in synapse
signal release
organelle localization by membrane tethering
membrane docking
neurotransmitter transport
regulation of synaptic plasticity
calmodulin binding
developmental maturation
synapse organization
vesicle organization