UNC50 [The Human Chemical-Genetic Interaction Map Project]

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======= UNC50 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UNC50
  * **<color #00a2e8>Official Name</color>**: unc-50 inner nuclear membrane RNA binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25972|25972]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53HI1|Q53HI1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UNC50&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UNC50|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617826|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UNC-50|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear inner membrane|
|integral component of Golgi membrane|
|RNA binding|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-4.81|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-4.25|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-4.19|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-3.71|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.34|
|[[:results:exp169|BH1 1μM R04 exp169]]|-3.23|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-3.21|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-3.01|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.79|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.61|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.59|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-2.57|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.4|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.35|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.28|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-2.22|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.17|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.08|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.98|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.83|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.72|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.71|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cog7|COG7]]|0.637|
|[[:human genes:c:cog5|COG5]]|0.613|
|[[:human genes:s:scap|SCAP]]|0.549|
|[[:human genes:c:cog6|COG6]]|0.546|
|[[:human genes:r:rab1b|RAB1B]]|0.529|
|[[:human genes:g:gpr107|GPR107]]|0.507|
|[[:human genes:s:slc39a9|SLC39A9]]|0.481|
|[[:human genes:m:mtmr6|MTMR6]]|0.474|
|[[:human genes:m:mbtps1|MBTPS1]]|0.471|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.459|
|[[:human genes:s:sgms1|SGMS1]]|0.455|
|[[:human genes:r:rgp1|RGP1]]|0.453|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.445|
|[[:human genes:s:scyl1|SCYL1]]|0.442|
|[[:human genes:k:kiaa1432|KIAA1432]]|0.438|
|[[:human genes:c:c12orf49|C12orf49]]|0.435|
|[[:human genes:c:ccdc132|CCDC132]]|0.426|
|[[:human genes:c:c10orf76|C10orf76]]|0.422|
|[[:human genes:a:arl1|ARL1]]|0.416|
|[[:human genes:w:wdr7|WDR7]]|0.413|
|[[:human genes:c:chka|CHKA]]|0.408|
|[[:human genes:m:mtmr9|MTMR9]]|0.404|
|[[:human genes:c:col4a3bp|COL4A3BP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 67/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|4/28|
|bone|3/26|
|breast|2/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|10/21|
|liver|5/20|
|lung|10/75|
|lymphocyte|3/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10081
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UNC50 Expression in NALM6 Cells: 4.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>