UNC50 [The Human Chemical-Genetic Interaction Map Project]

Gene Information

Official Symbol: UNC50
Official Name: unc-50 inner nuclear membrane RNA binding protein
Aliases and Previous Symbols: N/A
Entrez ID: 25972
UniProt: Q53HI1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Fluvastatin 2.2μM R06 exp282	-4.81
Bafilomycin-A1 0.009μM R08 exp454	-4.25
Cerivastatin 0.15μM R05 exp226	-4.19
Q15 1 to 2μM on day4 R04 exp164	-3.71
Clomiphene 4.4μM R02 exp68	-3.34
BH1 1μM R04 exp169	-3.23
Cryptotanshinone 12μM R05 exp227	-3.21
UM0011500 10μM R05 exp246	-3.01
CFI-400945 25μM R08 exp469	-2.79
Ibrutinib 10μM R08 exp442	-2.61
Nicotine 3000μM R08 exp510	-2.59
Vinblastine 0.2μM R03 exp108	-2.57
Q15 2.7μM R02 exp79	-2.4
BVD-523 15μM R02 exp67	-2.35
Vemurafenib 6.6μM R02 exp89	-2.28
L-74142 5μM R03 exp131	-2.22
BS-181 20μM R08 exp461	-2.17
UM0011500 5μM R05 exp245	-2.08
Vemurafenib 6.6μM R08 exp434	-1.98
Chlorpromazine 10μM R07 exp344	-1.83
Radicicol 0.16μM R05 exp242	-1.72
Ribavirin 10 to 15μM on day4 R04 exp160	-1.71
Nifuroxazide 5μM R03 exp102	1.82

Gene	Correlation
COG7	0.637
COG5	0.613
SCAP	0.549
COG6	0.546
RAB1B	0.529
GPR107	0.507
SLC39A9	0.481
MTMR6	0.474
MBTPS1	0.471
VKORC1L1	0.459
SGMS1	0.455
RGP1	0.453
TBC1D23	0.445
SCYL1	0.442
KIAA1432	0.438
C12orf49	0.435
CCDC132	0.426
C10orf76	0.422
ARL1	0.416
WDR7	0.413
CHKA	0.408
MTMR9	0.404
COL4A3BP	0.4

Global Fraction of Cell Lines Where Essential: 67/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	4/28
bone	3/26
breast	2/33
central nervous system	4/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	10/21
liver	5/20
lung	10/75
lymphocyte	3/16
ovary	1/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	2/15
prostate	0/1
skin	4/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	4/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10081
Expression level (log2 read counts): 4.59

Expression Distribution

Last modified: 2026/01/07 22:37
by 127.0.0.1