UNG [The Human Chemical-Genetic Interaction Map Project]

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======= UNG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UNG
  * **<color #00a2e8>Official Name</color>**: uracil DNA glycosylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7374|7374]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13051|P13051]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UNG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UNG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191525|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UDG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|base-excision repair, AP site formation via deaminated base removal|
|uracil DNA N-glycosylase activity|
|depyrimidination|
|base-excision repair, AP site formation|
|pyrimidine deoxyribonucleotide catabolic process|
|pyrimidine nucleotide catabolic process|
|ribosomal small subunit binding|
|somatic hypermutation of immunoglobulin genes|
|somatic diversification of immune receptors via somatic mutation|
|somatic diversification of immunoglobulins involved in immune response|
|somatic recombination of immunoglobulin genes involved in immune response|
|isotype switching|
|deoxyribonucleotide catabolic process|
|pyrimidine deoxyribonucleotide metabolic process|
|deoxyribose phosphate catabolic process|
|somatic recombination of immunoglobulin gene segments|
|immunoglobulin production involved in immunoglobulin mediated immune response|
|2-deoxyribonucleotide metabolic process|
|deoxyribose phosphate metabolic process|
|deoxyribonucleotide metabolic process|
|somatic diversification of immune receptors via germline recombination within a single locus|
|somatic cell DNA recombination|
|somatic diversification of immunoglobulins|
|base-excision repair|
|pyrimidine-containing compound catabolic process|
|B cell activation involved in immune response|
|somatic diversification of immune receptors|
|damaged DNA binding|
|pyrimidine nucleotide metabolic process|
|nucleotide catabolic process|
|nucleoside phosphate catabolic process|
|DNA modification|
|pyrimidine-containing compound metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|lymphocyte activation involved in immune response|
|organophosphate catabolic process|
|B cell activation|
|immunoglobulin production|
|production of molecular mediator of immune response|
|carbohydrate derivative catabolic process|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|DNA recombination|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|nucleobase-containing compound catabolic process|
|lymphocyte activation|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|DNA repair|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|viral process|
|DNA metabolic process|
|leukocyte mediated immunity|
|cellular response to DNA damage stimulus|
|symbiotic process|
|interspecies interaction between organisms|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|leukocyte activation|
|negative regulation of cell death|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|cellular response to stress|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-4.59|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.26|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.7|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.72|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.83|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.85|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.02|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9159
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UNG Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>