UNG

Gene Information

Official Symbol: UNG
Official Name: uracil DNA glycosylase
Aliases and Previous Symbols: N/A
Entrez ID: 7374
UniProt: P13051
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010].
UniProt Summary: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trimetrexate 0.03μM R08 exp535	-4.59
5-Fluorouracil 2μM R00 exp1	-2.26
A-395 10μM R05 exp218	1.7
FBS-Wisent 0.1 R07 exp426	1.72
Tanespimycin 14μM R08 exp527	1.83
Aphidicolin 0.4μM R08 exp440	1.85
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.02
GSK-J4 1.5μM R08 exp441	2.1

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9159
Expression level (log2 read counts): 6.24

Expression Distribution

base-excision repair, AP site formation via deaminated base removal
uracil DNA N-glycosylase activity
depyrimidination
base-excision repair, AP site formation
pyrimidine deoxyribonucleotide catabolic process
pyrimidine nucleotide catabolic process
ribosomal small subunit binding
somatic hypermutation of immunoglobulin genes
somatic diversification of immune receptors via somatic mutation
somatic diversification of immunoglobulins involved in immune response
somatic recombination of immunoglobulin genes involved in immune response
isotype switching
deoxyribonucleotide catabolic process
pyrimidine deoxyribonucleotide metabolic process
deoxyribose phosphate catabolic process
somatic recombination of immunoglobulin gene segments
immunoglobulin production involved in immunoglobulin mediated immune response
2-deoxyribonucleotide metabolic process
deoxyribose phosphate metabolic process
deoxyribonucleotide metabolic process
somatic diversification of immune receptors via germline recombination within a single locus
somatic cell DNA recombination
somatic diversification of immunoglobulins
base-excision repair
pyrimidine-containing compound catabolic process
B cell activation involved in immune response
somatic diversification of immune receptors
damaged DNA binding
pyrimidine nucleotide metabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
DNA modification
pyrimidine-containing compound metabolic process
nucleobase-containing small molecule biosynthetic process
lymphocyte activation involved in immune response
organophosphate catabolic process
B cell activation
immunoglobulin production
production of molecular mediator of immune response
carbohydrate derivative catabolic process